Our 10 Recommendations for the Best Methylfolate Supplement:
The 10 Best Methylfolate Supplement Reviews:
Bestseller No. 1 
L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate
- L-METHYLFOLATE: A metabolically active form of Folic Acid, also known as Folate or B-9 Vitamin!
- COMPLETE FORMULA: Quick-release capsules deliver 25,000 mcg Folate (15 mg L-METHYLFOLATE)
- ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living.
- CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
- NATURALLY FREE OF: Gluten, Wheat, Yeast, Lactose, Soy, Artificial Flavor, Preservatives and Non-GMO
SaleBestseller No. 2 
NOW Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets
- CO-ENZYME B VITAMIN/1,000 mg TABLETS: Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.*
- METABOLICALLY ACTIVE FOLATE*/SUPERIOR BIOAVAILABLITY: Quatrefolic is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.
- CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Vegan/Vegetarian
- GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
- Packaged in the USA by a family owned and operated company since 1968
SaleBestseller No. 3 
Life Extension Optimized Folate (L-Methylfolate) – Supports Heart & Brain Health – Non-GMO, Gluten-Free, Vegetarian –1700 mcg DFE — 100 Vegetarian Tablets
- BIOLOGICALLY ACTIVE FOLIC ACID — Our Optimized Folate formula promotes both cardiovascular and cognitive health with 1700 mcg of folate in the form of 5-MTHF (L-Methylfolate), the metabolically active form of folic acid.
- WHY FOLATE? – Maintaining normal levels of homocysteine, a metabolic byproduct, is associated with heart and brain health. Folate, a B vitamin, helps maintain homocysteine levels already within normal range. However, not everyone can efficiently convert folate to its biologically active form. Our formula provides 5-MTHF, so you don’t have to.
- HEART & BRAIN-FRIENDLY NUTRIENT – Because folate helps inhibit excess homocysteine, folate supports healthy levels of this important cardiovascular biomarker. Since healthy homocysteine levels have been associated with cognitive health, getting enough folate is especially crucial for individuals who want to maintain brain health.
- INGREDIENTS MATTER - Sourced using only the finest raw ingredients with the purity and potency your body deserves. The majority of our products are non-GMO, gluten-free, and manufactured in the USA—and a Certificate of Analysis is available for every product we produce.
- LIVE YOUR HEALTHIEST LIFE - For over 40 years, we’ve been developing advanced, effective formulas made with the highest standards and based on the latest scientific findings. We believe the answers to a healthier, richer life are within reach, and that rigorous scientific research is the path to get us there. Our formulations are created using the ingredients and dosages used in the studies that inspired them, ensuring that maximum bioavailability and efficacy is achieved.
Bestseller No. 4 
Douglas Laboratories Methyl Folate L-5-MTHF | 1,000 mcg Metafolin Identical to The Naturally Occurring Form of Folate to Support Overall Health * | 60 Tablets
- Contains 5-MTHF: Metafolin is directly usable by the body and has been shown to be the only form of folate to cross the blood-brain barrier.*
- Essential B Vitamin: Folate is a water-soluble essential B vitamin found in many foods, including leafy green vegetables, citrus fruits, and beans essential for a variety of processes in the body.*
- Vitamins/Minerals/Amino Acids: supplement formulated to provide beneficial support in filling important nutrient gaps.*
- Our uncompromising operational practices at our state-of-the-art manufacturing facilities surpass GMP standards and manufacturing regulations. All of our products are GMO-free.
- For 65 years, Douglas Laboratories has been dedicated to meeting the needs of healthcare professionals. As a globally recognized leader in the development of innovative, science-based nutritional supplements, we strive to help healthcare professionals and their patients push their potential for healthy living, today and in the future.*
Bestseller No. 5 
Thorne 5-MTHF 1mg - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules
- Healthy Methylation: A breakthrough in active folate supplementation for healthy methylation*
- Positivity: Supports a healthy outlook*
- Nerves & Circulation: Supports healthy blood vessel and nerve function*
- Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health*
- Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams
Bestseller No. 6 
MethylPro 15mg L-Methylfolate (90 Capsules) - Professional Strength Active Methyl Folate, 5-MTHF Supplement for Mood, Homocysteine Methylation + Immune Support, Gluten-Free with No Fillers
- The Leader In Faster, Active Folate - Approximately half the US population may have difficulty converting folate into its active form. MethylPro is the leading nutraceutical line featuring l-methylfolate, the most advanced form for better results.*
- Professional Strength - Many methylfolate products contain mcg or 1mg amounts. MethylPro offers a range of potent therapeutic doses. This 15 mg dose is our strongest, for a difference you can feel.*
- Brain & Mood Support - Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, energy, hormones and mood stability. This is the only form of folate to cross the blood-brain-barrier.*
- Promotes Cardiovascular & Nerve Health - May help promote heart health & healthy peripheral nerve function by supporting already healthy homocysteine levels and nitric oxide production.*
- No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. The only additional ingredient is the amino acid glycine. This product is free of soy, gluten, dairy, eggs, and nuts. Take only as directed under the supervision of a Physician.*
Bestseller No. 7 
MD. Life L-Methylfolate 15 mg - Active Folate Supplement - Doctor Designed Maximum Strength 5 Mthf Supplement L-Methylfolate 15mg - 90 Vegan Capsules - Essential Amino Acids & Methylated Folate
- ACTIVE FOLATE THAT WORKS - This L-methylfolate 15 mg formula contains the ingredients necessary for your body to properly utilize folic acid, also known as a complex b9 vitamin. Unlike folic acid, the synthetic form of vitamin B9, methylfolate is the already converted form of folate people can easily use without the need of the MTHFR enzyme.*
- SYNTHESIS AND REPAIR* - Methylfolate 15 mg, the most active form, is essential in the production and maintenance of new cells. About half the United States may have difficulty converting folate into its active folate.*
- THIRD PARTY TESTED FOR PURITY - All our l methyl folate 15mg supplements undergo extensive third-party lab testing to maintain the highest level of quality and purity in the manufacturing of our products. Having third party certification means these products comply with specific standards set for safety, quality, and performance. These products are also made and packaged in the USA.
- MOOD & BRAIN SUPPORT* – MD Life’s L methylfolate 15mg is a great choice for mood support. Sleep, concentration, energy, mood stability and hormone support are assisted by methylfolate.
- DOCTOR DESIGNED PROFESSIONAL STRENGTH - Many l-methylfolate 15mg products contain small amounts. We offer a wide range of potent doses. This l-methylfolate 15 mg dose is our most potent, for a big difference you can see.*
SaleBestseller No. 8 
Jarrow Formulas Methyl Folate 400 Mcg - 60 Veggie Caps - Dietary Supplement - Highly Biologically Active Form Of Folate - 4th Generation Folic Acid Technology - 60 Servings (PACKAGING MAY VARY)
- Methyl Folate - Jarrow Formulas Methyl Folate) is a highly biologically active form of folate; Due to the body’s limited ability to convert synthetic folic acid into the active form of folate, supplementation with 5-MTHF is preferable.
- Quatrefolic - Featuring 4th generation development in folate delivery, our patent-pending technology formula features increased stability and bioavailability.
- Convenient Veggie Capsules - Each capsule delivers 400 micrograms(mcg) of methyl folate; Take 1 capsule per day, with or without a meal, or as directed by your qualified healthcare professional.
- Superior Science, Smarter Formulas - Informed by strong scientific research, Jarrow Formulas products are carefully crafted to ensure you get the benefit of each and every vitamin, mineral and supplement.
Bestseller No. 9 
L Methyl Folate 15mg plus Methyl B12 Cofactor - Professional Strength, Active 5-MTHF Form - Supports Mood, Homocysteine Methylation, Cognition – Bioactive forms of Vitamin B9 & B12 (60 Count Capsules)
- PROFESSIONAL STRENGTH: Provides clinically validated dosage of 15mg L Methyl folate in the 5-MTHF calcium salt form. This is the most active form of Folate.
- ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
- ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is crucial for those with methylation issues that cannot properly process folic acid.
- BRAIN, MOOD & ENERGY SUPPORT: Essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.*
- CARDIOVASCULAR, NITRIC OXIDE & NERVE SUPPORT: Supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.
Bestseller No. 10 
Thorne 5-MTHF 5mg - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules
- Healthy Methylation: A breakthrough in active folate supplementation for healthy methylation*
- Positivity: Supports a healthy outlook*
- Nerves & Circulation: Supports healthy blood vessel and nerve function*
- Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health*
- Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams
Last update on 2023-03-23 / Affiliate links / Images from Amazon Product Advertising API